Aleukemic Mast Cell Leukemia (aMCL) - Clinical Characteristics and Outcomes
نویسندگان
چکیده
منابع مشابه
Aleukemic variant of mast cell leukemia.
A woman was admitted with fatigue, icterus, thrombocytopenia (77 109/L), normocytic anemia (9.8 g/dL), and a normal white blood cell count (8.5 109/L). The peripheral blood smear showed metamyelocytes, myelocytes, monocytes, erythroblasts, and atypical cells with bilobulated nuclei resembling basophil granulocytes (left panel of figure). In the bone marrow there was a nearly complete infiltrati...
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Mast cell leukemia is a rare variant of mastocytosis, accounting for less than 1% of all mast cell disease and pose one of the greater challenges in the management of these patients, with a grave prognosis. Diagnosis of this neoplasm rests on the detection of abnormal mast cells in marrow and subsequent spill over to the peripheral blood. We report a case of aleukemic variant of mast cell leuke...
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Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involveme...
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Dear Editor, Mastocytosis refers to a group of rare clinical disorders, in which mast cells expand abnormally and accumulate in various organs [1, 2]. Mast cell leukemia (MCL) is a rare and aggressive form of systemic mastocytosis and accounts for 1% of all mastocytosis [3]. Due to its rarity, making a prompt diagnosis is difficult when unaware of the morphological characters of the abnormal ma...
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A 46-year-old man presented with nodular skin lesions, a biopsy specimen of which demonstrated a poorly differentiated malignancy. Touch preparations with histochemical staining and electron microscopy confirmed leukemia cutis. Results from a bone marrow aspirate disclosed focal areas of increased myeloblasts, and cytogenetic analysis revealed an abnormal karyotype as follows 46,XY, t(1;2) (q44...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.4255.4255